4.54 from 30 votes

John Wayne Casserole

Yummy biscuit crust is topped with delicious layers of ground beef, veggies, and lots and lots of cheese. This John Wayne Casserole will become a family favorite!
Prep: 15 minutes
Cook: 40 minutes
Total: 1 hour 5 minutes
Servings: 6 servings
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Ingredients 

  • 1 lb ground beef
  • ½ white onion, diced
  • 1 ½ tbsp taco seasoning
  • ¼ cup water
  • 1 can Rotel Diced Tomatoes and Green Chiles
  • 1 can corn, drained
  • 1 cup shredded sharp cheddar cheese
  • 1 cup mozzarella cheese

Bisquick Mixture

  • 2 cups Bisquick
  • 1 cup water

Creamy Mixture

  • ¼ cup mayonnaise
  • 7.5 oz chive and onion cream cheese
  • tsp pepper
  • tsp garlic powder

Toppings (optional)

  • chopped cherry tomatoes
  • sour cream
  • more cheese
  • cilantro

Instructions 

  • Preheat oven to 325℉.
  • Add the ground beef and onion to a skillet over medium-high heat, and cook until the beef is cooked through. Remove any excess grease, then add in the taco seasoning and water and simmer for 3 minutes. Add in the can of Rotel, can of corn, and stir to combine.
  • Make the Bisquick mixture by combining the Bisquick and water in a small bowl. Stir until well combined and set aside.
  • Whisk the ingredients for the creamy mixture together in a small bowl. Set aside.
  • Grease a 9×13 baking dish with non-stick spray. Spread the Bisquick mixture evenly in the bottom of the pan. Pour the ground beef mixture on top, then spread the creamy mixture over the ground beef, then sprinkle with the cheddar and mozzarella. Bake for 40 minutes. Let sit for 10 minutes. Top with your favorite toppings and enjoy!

Video

Nutrition

Calories: 730kcal | Carbohydrates: 47g | Protein: 30g | Fat: 48g | Saturated Fat: 20g | Polyunsaturated Fat: 6g | Monounsaturated Fat: 15g | Trans Fat: 1g | Cholesterol: 114mg | Sodium: 1086mg | Potassium: 592mg | Fiber: 3g | Sugar: 11g | Vitamin A: 978IU | Vitamin C: 11mg | Calcium: 383mg | Iron: 4mg

Nutrition information is automatically calculated, so should only be used as an approximation.

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About Julia Pacheco

Hello, I’m Julia Pacheco, and I’m so glad you’re here! I’m a published cookbook author with a passion for creating delicious, budget-friendly meals. My blog focuses on recipes that are accessible and enjoyable, because I truly believe in the power of food to heal, inspire, and bring people together. From early lessons in the kitchen with my mom to navigating life on WIC and food stamps, I’ve learned the value of making every meal count. Cooking has been my creative outlet, a way to connect with others, and it even helped me land my dream job.

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18 Comments

  1. Michaela Browning says:

    5 stars

    I am so excited to try this recipe for our family! This looks like a win and affordable! Thanks, from one momma to another!

  2. Desiree says:

    5 stars

    I love this!! Saved it in my top favs!! Wonderful flavor! Will make again soon!!

  3. Dez says:

    5 stars

    5 stars! This is amazing! Absolutely love it!!

  4. Rose says:

    5 stars

    This recipe was so delicious and easy to make. I followed the recipe as written.

  5. Sincerely B says:

    5 stars

    My husband and son love this recipe and its so easy to put together! Do you know if it’s possible to make this as a freezer casserole? Have you experimented with that a bit? I’d love to just have one ready to go in the freezer but not sure how the bisquick would hold up being thawed and reheated….. thanks for any input!

    1. Susan says:

      My question, also.

    2. Jojoleen says:

      Did you ever try freezing this? I’ve been wondering the same thing…!!